Search on: TISSUE INHIBITOR OF METALLOPROTEINASE-1 
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Descriptor English:   Tissue Inhibitor of Metalloproteinase-1 
Descriptor Spanish:   Inhibidor Tisular de Metaloproteinasa-1 
Descriptor Portuguese:   Inibidor Tecidual de Metaloproteinase-1 
Synonyms English:   TIMP-1  
Tree Number:   D12.776.926.450
Definition English:   A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro. 
History Note English:   98; see TISSUE-INHIBITOR OF METALLOPROTEINASE-1 (NM) 1980-97 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33426 
Unique Identifier:   D019715 

Occurrence in VHL:
 

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